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The U.S. Food and Drug Administration has approved Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) as treatment option for chronic weight-loss in addition to a reduced-calorie diet and physical activity.

Using two separate drugs to lose weight can be very effective there are combinations while watching FDA now awaiting approval. When dealing with weight-loss and the people that go through it you need to err to the side of caution and permit the FDA do its job and demand some investigation be done so the public understands the side effects and dangers of the medications before we bring them. Keep in mind that drug companies come in business to generate money and that they would say everything to keep people on their medications.

Researchers found out that participants using this drug for the year, lost excess weight within 4 weeks and have kept the extra weight off throughout the 56 weeks of the study. Contrave is often a combination in the drugs naltrexone and bupropion, which appears to reflect a brand new trend of weight-loss drugs that are made up of many active ingredient, which can make them more effective and safer.

Combo-pilling is the newest fad or even better the newest to come under scrutiny and for that reason it is just more publicly known although in the past, comb-pilling for weight loss has been around since the eighties. The biggest reason that by using a combination of pills is now popular could be the fact that as of right now there aren't any long term prescription slimming capsules that have been approved by the FDA besides orlistat. The truly disturbing part is doctors are prescribing these combinations of medications even though some of the combinations happen to be rejected or have yet to be licensed by the FDA.

Seizures certainly are a side effect with Contrave and really should not be taken in those with seizure disorders. The drug could also raise hypertension and heartrate, and mustn't be used in people with a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy with the drug.

The FDA also warned that Contrave can raise blood pressure levels and pulse rate and must 't be used in patients with uncontrolled high blood pressure level, along with by a person with heart-related and cerebrovascular (circulatory dysfunction impacting the mind) disease. Patients using a history of heart attack or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes using a boxed warning to alert physicians and patients to the increased chance of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stop smoking.

"This is the first drug I'm conscious of that targets both the appetite and reward centres inside brain," he explained.